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since observed maximal placoncentrations after multiple oral doses are higher than expected based on single-dose data.
Protonix may rarely be habit forming. Protonix should be avoided in patients with a history.
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This is known as physical DEPENDENCE. If you suddenly stop taking Protonix , you may experience WITHDRAWAL symptoms including anxiety;
Ask your health care provider if Protonix may interact with other medicines that you take.
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The analgesic activity of Protonix is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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A single i.m. dose of Protonix is useful pre-treatment to minimize the risk of acid aspiration during operation,
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Protonix is used to relieve moderate to moderately severe pain.
We investigated the antacid analgesic value of a single dose of i.m. Protonix given 1 h before elective ,
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Protonix should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
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For Protonix, the following should be considered:The suitability of Protonix suppositories for inclusion in our hospital formulary for the treatment of mild to moderate post-operative pain was evaluated.
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If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Protonix while you are pregnant.
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Nalbuphine consumption in the first 24 h after operation was reduced by 35% in the Protonix group.
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which may affect the therapeutic response (see PRECAUTIONS – Drug Interactions).
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Protonix is well absorbed orally with an absolute bioavailability of 75%. Protonix has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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In an open randomized trial, rectal Protonix was compared with our standard treatment acetaminophen/codeine suppositories. We expected Protonix to be equally effective as our current standard but with fewer side effects.
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